Neptunium was the first transuranium element to be synthesized. In nature it appears only as a trace neutron-activation product in uranium ores; industrially it is separated mainly as a by-product of reactor irradiation of uranium fuel. Its most stable isotope, neptunium-237, has a half-life of about 2.14 million years. It is intensely radioactive and has no consumer or industrial-scale practical use. Today neptunium is studied chiefly in nuclear-fuel reprocessing and radioactive-waste disposal research, where it is the representative long-lived minor actinide used to assess the long-term radiological risk of high-level waste; there is also limited research on the possibility of irradiating neptunium-237 to produce plutonium-238, the fuel of space-based radioisotope heat sources.
Neptunium compounds such as neptunium dioxide (NpO2) and neptunium hexafluoride (NpF6) are prepared only in trace amounts in nuclear-fuel reprocessing and radiochemical laboratories, where they are used in actinide separation flowsheets and thermodynamic-property studies; they do not enter consumer products.